Twenty-year trajectories of morbidity in individuals with and without osteoarthritis
Authors' conclusion
Our findings suggest that individuals with OA face an almost threefold higher risk of developing severe multimorbidity.
Study context
- Population
- Individuals aged 40+ years, Skåne region, Sweden (≈1.4 million residents)matched cohort
- Participants
- 9,846 vs 9,846
- Exposure
- Incident osteoarthritis (OA) vs OA-free matched references
- OAn = 9,846
- Referencesn = 9,846reference
- Outcome
- Morbidity count trajectories (67 common chronic conditions)
- Follow-up
- 1998 to 2019
Methodological detailsprospectively collected healthcare data, matched on birth year, sex, and year of death or moving outside the region, group-based trajectory modelling
- Prospectively collected healthcare data
- Matched on birth year, sex, and year of death or moving outside the region
- Group-based trajectory modelling
Main finding
As reported in the abstract
Adjusted RR of belonging to multimorbidity trajectory class (vs no-chronic-condition class)
Each group vs referencesEstimate (CI)
OA
adjusted relative risk, class 1 1.29(1.12–1.48)
OA
adjusted relative risk, class 4 2.45(2.12–2.83)
- No-chronic-condition class (cases and references)
- 1296
Observational data: associations, not effects.
Further findings
| Outcome | Class 1 | Class 4 |
|---|---|---|
| Count of chronic conditions at end of follow-up, by class | mean 2.9 (SD 1.7) | 9.6 (SD 2.6) |
Original publication
Twenty-year trajectories of morbidity in individuals with and without osteoarthritis. RMD Open. Published 2 July 2024. doi:10.
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