Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: An individual participant data meta-analysis of 18,807 hips from the World COACH consortium

Riedstra, NS; Boel, F; van Buuren, MMA; Ahedi, H; Arbabi, V; Arden, N; Baart, SJ; Bierma-Zeinstra, SMA; Cicuttini, FM; Cootes, TF; Crossley, KM; Felson, DT; Giellis, WP; Heerey, J; Jones, G; Kluzek, S; Lane, NE; Lindner, C; Lynch, JA; van Meurs, JBJ; Mosler, A; Nelson, AE; Nevitt, MC; Oei, EH; Runhaar, J; Tang, J; Weinans, H; Agricola, R

doi:10.1016/j.joca.2024.12.001

Osteoarthritis

Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: An individual participant data meta-analysis of 18,807 hips from the World COACH consortium

Osteoarthritis CartilagePublished 8 Dec 2024Individual participant data meta-analysis

Pooled result · Incident RHOAResultAdjusted odds ratio 1.80 95% CI 1.40–2.34

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Authors' conclusion

AD was consistently associated with incident RHOA.

Study context

Population: Hips free of radiographic hip osteoarthritis (RHOA) at baseline with follow-up within 4–8 years, World COACH consortium; age 61.84 (± 8.32) years, body mass index (BMI) 27.40 (± 4.49) kg/m², 70.1% womenhips from 9 studies
Participants: 18,807 participants

Comparison: Acetabular dysplasia vs no acetabular dysplasia
Acetabular dysplasia (AD)n = 4,766
Outcome: Incident radiographic hip OA (RHOA)
Follow-up: 4-8 years

Methodological detailsWorld COACH consortium, logistic regression with generalized mixed effects (3 levels), adjusted for age, biological sex and BMI

World COACH consortium
Logistic regression with generalized mixed effects (3 levels)
Adjusted for age, biological sex and BMI

Pooled result

Incident RHOA · 4-8 years (mean 5.8 ±1.6)

Adjusted odds ratio

1.80

95% CI 1.40–2.34

ADvs non-AD

aOR 1.80 (95% CI 1.40–2.34)

As reported in the abstract

Hips developing incident RHOA (all hips): 378 (2.0%)

Further pooled results

Outcome	RR
Incident RHOA, AD vs non-AD, descriptive subgroups · 4-8 yearsAD vs non-AD · age group 61-70 · descriptive statistics	1.70
Incident RHOA, AD vs non-AD, descriptive subgroups · 4-8 yearsAD vs non-AD · BMI<25 · descriptive statistics	1.66
Incident RHOA, AD vs non-AD, descriptive subgroups · 4-8 yearsAD vs non-AD · female hips · descriptive statistics	1.73

Incident RHOA, other AD definitions (Wiberg center edge angle (WCEA)≤20°, ADR ≤250, modified acetabular index (mAI) ≥ 13°, combination) · 4-8 years

All other AD definitions associated with incident RHOA; aOR range: 1.52 95% CI 1.19-1.94 to 1.96 95% CI 1.26-3.02

Original publication

Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: An individual participant data meta-analysis of 18,807 hips from the World COACH consortium. Osteoarthritis Cartilage. Published 8 December 2024. doi:10.1016/j.joca.2024.12.001

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