Early-stage vs established knee osteoarthritis: A comparative observational study on prevalence and changes in pain, function and quality of life after supervised exercise and education among 10,365 patients
Authors' conclusion
Patients with early-stage KOA achieved comparable improvements at 3 and 12 months to those with established KOA
Study context
- Population
- Patients with knee OA from Good Life with osteoArthritis in Denmark (GLA:D®) undertaking supervised exercise and education
- Participants
- 10,365 patients
- Exposure
- Early-stage knee osteoarthritis (KOA) vs potential early-stage KOA vs established KOA undertaking supervised exercise and education (GLA:D®)
- Outcome
- Changes in VAS pain intensity (0-100mm), KOOS Quality of Life (QoL) (0-100), 40 m Walk test and 30 s chair-stand test; proportion achieving minimal clinically important improvements (MCIIs)
- Follow-up
- 3 and 12 months
Methodological detailsmixed-effects models
- Mixed-effects models
Main finding
As reported in the abstract
VAS pain intensity, mean change · 12 months
VAS pain intensity, mean change · 12 months Established KOA mean −15 (95% CI −15–-14) · Early-stage KOA mean −14 (95% CI −15–-13) · Potential early-stage KOA −9.8 (95% CI −11.3–-8.2)
≥MCII
Observational data: associations, not effects.
Further findings
Proportion of patients (61%, 27%, 10%)
KOOS QoL, ≥MCII · 12 months
Walking speed, ≥MCII · 3 months
Chair-stands, ≥MCII · 3 months
| Outcome | Established KOA | Early-stage KOA | Potential early-stage KOA |
|---|---|---|---|
| Baseline knee pain | mean 51 (SD 22) | mean 45 (SD 22) | 34 (SD 32.7) |
Baseline knee pain
- Potential early-stage KOA had lower baseline pain than either group
Original publication
Early-stage vs established knee osteoarthritis: A comparative observational study on prevalence and changes in pain, function and quality of life after supervised exercise and education among 10,365 patients. Osteoarthritis Cartilage. Published 29 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →