Inflammaging contributes to osteoarthritis development and human microbiota variations and vice versa: A systematic review
Authors' conclusion
Several hypotheses have been made on the associations between microbiota changes and inflammation. They mainly advocate that those changes in the gastrointestinal tract affect gut permeability, which alters the immune system, leading to OA progression.
Study context
- Population
- Human osteoarthritis (OA) patients; studies of microbiota and its relationship with inflammaging, the innate immune system and OA24 studies
- Outcome
- Mainly microbiota identification, improvement or deterioration of OA pain, stiffness or inflammation
Methodological detailsPRISMA, PICO model, Web of Science, Scopus, Cochrane Library for clinical trials and PubMed searched
- PRISMA
- PICO model
- Web of Science, Scopus, Cochrane Library for clinical trials and PubMed searched
Pooled result
As reported in the abstract
- Five preliminary clinical trials used pro-prebiotics to treat OA patients; results not conclusive, methodology needs improvement
- 5
Original publication
Inflammaging contributes to osteoarthritis development and human microbiota variations and vice versa: A systematic review. Osteoarthritis Cartilage. Published 28 November 2024. doi:10.
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