Infrapatellar fat pad as a source of biomarkers and therapeutic target for knee osteoarthritis
Authors' conclusion
Imaging, biochemical, and molecular studies indicate OA potential biomarkers in the IPFP related to inflammation, lipid dysregulation, and fibrosis.
Study context
- Population
- Human osteoarthritis (OA) patients; studies of the infrapatellar fat pad (IPFP) identifying imaging, biochemical and molecular biomarkers
- Participants
- 61 studies
- Outcome
- IPFP biomarkers of OA
Methodological detailsPubMed search, June 2024, cross-sectional and longitudinal studies
- PubMed search, June 2024
- Cross-sectional and longitudinal studies
Pooled result
As reported in the abstract
Imaging studies, mostly magnetic resonance imaging (MRI): semiquantitative and quantitative imaging biomarkers linked to inflammation, fibrosis, pain and joint degeneration
n = 47
Biochemical and molecular studies: increase in IL-6, FABP4, adiponectin and lysophosphatidylcholine (LysoPC) in the IPFP during OA progression
n = 14
Original publication
Infrapatellar fat pad as a source of biomarkers and therapeutic target for knee osteoarthritis. Arthritis Res Ther. Published 5 April 2025. doi:10.
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