Modification of cardiovascular risk factors after viscosupplementation with hyaluronic acid in patients with symptomatic hip and knee osteoarthritis
Authors' conclusion
Intra-articular viscosupplementation with hyaluronic acid in symptomatic hip and knee osteoarthritis achieves a decrease in pain, potentially allowing patients to increase their physical activity levels, which helps control weight and BMI.
Study context
- Population
- Patients with symptomatic hip and knee OA meeting ACR clinical and radiological criteria, Kellgren-Lawrence grades I–IV
- Participants
- 101 patients
- Exposure
- Before vs after four intra-articular hyaluronic acid injections
- Outcome
- Modification of cardiovascular risk factor parameters after intra-articular hyaluronic acid injection
Main finding
As reported in the abstract
Modification of CV risk factor parameters after intra-articular hyaluronic acid · 24 months
- Reduction in pain (VAS), points
- 1.2 (p<0.001)
- Increase in physical activity
- 19.81% (p<0.001)
- Increase in physical activity frequency
- 21.8% (p=0.001)
- Significant decrease in total cholesterol in patients with pathological baseline levels
- p=0.002
- Significant decrease in LDL in patients with pathological baseline levels
- p=0.009
- Significant decrease in HDL in patients with pathological baseline levels
- p=0.023
- Significant decrease in triglycerides in patients with pathological baseline levels
- p=0.021
Observational data: associations, not effects.
Further findings
Lipid parameters in patients with pathological baseline levels
- Total cholesterol: significant decrease
- P = 0.002
- LDL: significant decrease
- P = 0.009
- HDL: significant decrease
- P = 0.023
- Triglycerides: significant decrease
- P = 0.021
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Modification of cardiovascular risk factors after viscosupplementation with hyaluronic acid in patients with symptomatic hip and knee osteoarthritis. Clin Exp Rheumatol. Published 1 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →