Risk factors for the development of knee osteoarthritis across the lifespan: A systematic review and meta-analysis
Study context
- Population
- Longitudinal cohort studies or RCTs evaluating participants who developed incident symptomatic and/or radiographic knee OA131 studies
- Outcome
- Incident radiographic knee OA
Methodological detailsrandom effects model, GRADE certainty of evidence, population attributable fractions
- Random effects model
- GRADE certainty of evidence
- Population attributable fractions
Pooled result
As reported in the abstract
Risk factors for incident radiographic knee OA (pooled analysis)
Odds ratio (95% CI)
Previous knee injury
2.67(1.41–5.05)
Older age
1.15(1.00–1.33)
High BMD
1.82(1.12–2.94)
Further pooled results
Population attributable fraction of incident radiographic knee OA
- Overweight/obesity and previous knee injury together accounted for
- 14%
Other modifiable risk factors
- Other modifiable risk factors, including occupational physical activity, also contribute to radiographic or symptomatic knee OA
Original publication
Risk factors for the development of knee osteoarthritis across the lifespan: A systematic review and meta-analysis. Osteoarthritis Cartilage. Published 31 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →