Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross‐Sectional Results From a Large Community‐Based Cohort
Authors' conclusion
We identified common US features in participants with and without KOA, along with significant associations between US features and rKOA, symptomatic rKOA, and symptoms. US-based diagnosis of rKOA shows promise for general use.
Study context
- Population
- Participants of the Johnston County Health Study (JoCoHS; 2019–2024), community-based cohort: 34% men, 25% Black, 10% Hispanic, mean age 55 years, mean body mass index (BMI) 33861 analysed (1,711 knees)
- Participants
- 902 participants
- Outcome
- Associations among US features of knee OA, radiographic knee OA (rKOA) and patient-reported symptoms; diagnostic accuracy of US definitions for rKOA
Methodological detailscommunity-based cohort, logistic regression adjusted for age, sex, race, ethnicity, BMI, education level, comorbidities and knee injury, radiographic KOA (rKOA) as gold standard, external validation
- Community-based cohort
- Logistic regression adjusted for age, sex, race, ethnicity, BMI, education level, comorbidities and knee injury
- rKOA as gold standard
- External validation
Main finding
As reported in the abstract
AUC of ultrasound (US) definition (mild osteophytes and mild cartilage damage) for diagnosing rKOA (validated in an external cohort)
0.76
Observational data: associations, not effects.
Further findings
Prevalence among knees
- Symptomatic knees
- Half
- rKOA
- one-third
- Symptomatic rKOA
- one in five
Original publication
Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross‐Sectional Results From a Large Community‐Based Cohort. Arthritis Rheumatol. Published 20 March 2025. doi:10.
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