CRP-Albumin-Lymphocyte index (CALLYI) as a risk-predicting biomarker in association with osteoarthritis
Main finding · OA risk, fully adjusted Model 3Result — go to the resultOdds ratio 0.72 95% CI 0.59–0.88Authors' conclusion
This study, utilizing NHANES statistics, is the first to establish a nonlinear negative relationship between CALLYI and OA, with no significant interaction observed in subgroup analyses.
Study context
- Population
- US adults in National Health and Nutrition Examination Survey (NHANES) 1999–20101,977 (10.62%) with osteoarthritis (OA)
- Participants
- 18,624 adults
- Exposure
- CALLYI Q4 vs Q1
- Outcome
- OA (association with CALLYI)
Methodological detailsweighted multiple regression models, restricted cubic splines, subgroup analyses, least absolute shrinkage and selection operator (LASSO) variable selection, nomogram prediction model
- Weighted multiple regression models
- Restricted cubic splines
- Subgroup analyses
- LASSO variable selection
- Nomogram prediction model
Main finding
OA risk, fully adjusted Model 3
Odds ratio
0.72
95% CI 0.59–0.88
P = 0.001
Q4vs Q1
OR 0.72 (95% CI 0.59–0.88); P = 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
CALLYI value
- Mean value of CALLYI (as printed)
- 5.13 (2.12,12.86)
Interactions in subgroup analyses
- No significant interactions
- P > 0.05
Non-linear relationship CALLYI–OA (restricted cubic splines (RCS))
- Significant non-linear relationship
- P < 0.0001
OA prediction model incorporating CALLYI
- AUC
- 0.825 (95% CI: 0.817-0.834)
- Decision curve analysis (DCA) indicated clinical significance
Original publication
CRP-Albumin-Lymphocyte index (CALLYI) as a risk-predicting biomarker in association with osteoarthritis. Arthritis Res Ther. Published 19 March 2025. doi:10.
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