Relationship between knee pain and depth-specific measures of proximal tibial subchondral bone density
Authors' conclusion
Lower subchondral proximal tibial BMD measures were associated with the prevalence of moderate knee pain in individuals with or at risk for knee OA, without differences by depth or compartment.
Study context
- Population
- Multicenter Osteoarthritis (MOST) study participants with knee CTs, with or at risk for knee osteoarthritis (OA) (mean age 61 years, 56.5% female, mean body mass index (BMI) 29 kg/m²)
- Participants
- 2,082 participants
- Exposure
- Compartment- and depth-specific proximal tibial subchondral bone mineral density (BMD) (per SD increase) vs presence of at least moderate knee pain
- Outcome
- Presence of at least moderate knee pain in the past 30 days (NRS 0-100 dichotomised at 40/100) in relation to subchondral BMD at depths 0-2.5, 2.5-5.0 and 5-10 mm
Methodological detailsmulticentre, binomial regression with generalized estimating equations, adjusted for age, sex, and BMI
- Multicentre
- Binomial regression with generalized estimating equations
- Adjusted for age, sex, and BMI
Main finding
As reported in the abstract
Prevalence of moderate knee pain per SD increase in average subchondral BMD
- Prevalence of moderate pain significantly lower for each SD unit increase in average subchondral BMD, after confounder adjustment, in each compartment
- Magnitude of association did not differ for increasing depths beneath the subchondral surface or between compartments
Observational data: associations, not effects.
Original publication
Relationship between knee pain and depth-specific measures of proximal tibial subchondral bone density. Osteoarthritis Cartilage. Published 13 March 2025. doi:10.
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