Osteoarthritis and hypertension: observational and Mendelian randomization analyses
Main finding · Hypertension (NHANES, adjusted for multiple confounding factors)Result — go to the resultOdds ratio 1.30 95% CI 0.97–1.73Authors' conclusion
Our study found that OA patients had a higher risk of hypertension only among males in the observational study. However, MR analysis did not uncover any causal relationship between OA and hypertension.
Study context
- Population
- Participants in National Health and Nutrition Examination Survey (NHANES) 2013 to 2020NHANES 2013–2020
- Participants
- 24,871 participants
- Exposure
- Osteoarthritis (OA) vs no OA, for hypertension
- Outcome
- Association between OA and hypertension
Methodological detailsretrospective, weighted logistic regression, Mendelian randomization, reverse Mendelian randomization (MR)
- Retrospective
- Weighted logistic regression
- Mendelian randomization
- Reverse MR
Main finding
As reported in the abstract
Hypertension (NHANES, adjusted for multiple confounding factors)
Odds ratio
1.30
95% CI 0.97–1.73
P = 0.089
OAvs No OA
OR 1.30 (95% CI 0.97–1.73); P = 0.089
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Hypertension in males (subgroup, NHANES) | 2.25 (1.17–4.32) | P = 0.019 | |
| 0.20.5125Odds ratio (log scale) |
Hypertension, MR (IVW) by OA phenotype
| OR (95% CI) | P value | ||
|---|---|---|---|
| Knee OAIVW | 1.024 (0.931–1.126) | P = 0.626 | |
| Hip OAIVW | 0.990 (0.941–1.042) | P = 0.704 | |
| Knee or hip OAIVW | 1.005 (0.915–1.105) | P = 0.911 | |
| OA from UK BiobankIVW | 0.796 (0.233–2.714) | P = 0.715 | |
| 0.20.5125Odds ratio (log scale) |
- Findings consistent across genders and in reverse MR
Original publication
Osteoarthritis and hypertension: observational and Mendelian randomization analyses. Arthritis Res Ther. Published 17 April 2024. doi:10.
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