Association of non-alcoholic fatty liver disease with self-reported osteoarthritis among the US adults
Authors' conclusion
NAFLD was positively correlated with OA.
Study context
- Population
- US adults in the 2017–2018 National Health and Nutrition Examination Survey (NHANES) cycle; Osteoarthritis (OA) based on self-reported data317 (12.8%) OA patients
- Participants
- 2,622 adults
- Exposure
- Non-alcoholic fatty liver disease (NAFLD) vs no NAFLD
- NAFLDn = 1,140
- Outcome
- Self-reported OA
Methodological detailsweighted multiple logistic regression, stratified analyses, sensitivity analysis with multiple imputation, propensity score matching
- Weighted multiple logistic regression
- Stratified analyses
- Sensitivity analysis with multiple imputation
- Propensity score matching
Main finding
As reported in the abstract
OA
NAFLD vs No NAFLDOdds ratio (95% CI)
Without adjustment
2.05(1.52–2.78)
After adjustment for covariates
1.72(1.26–2.34)
Observational data: associations, not effects.
Further findings
OA by subgroup (age, metabolic syndrome (MetS), sex, obesity, hs-CRP)
- Significant and consistent association in each subgroup stratified by age and MetS
- Stratified by sex, obesity and hs-CRP category, significant association only in females, those without obesity and those without hyper hs-CRP
- No interaction across subgroups
Original publication
Association of non-alcoholic fatty liver disease with self-reported osteoarthritis among the US adults. Arthritis Res Ther. Published 31 January 2024. doi:10.
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