How Do Nonsurgical Interventions Improve Pain and Physical Function in People With Osteoarthritis? A Scoping Review of Mediation Analysis Studies
Authors' conclusion
In knee OA, some evidence suggests that the benefits of 1) diet and exercise are mediated through changes in body weight, systemic inflammation, and self-efficacy; 2) exercise is mediated through changes in knee muscle strength and self-efficacy; and 3) high-expectation communication style is mediated through changes in self-efficacy.
Study context
- Population
- Mediation analyses of RCTs evaluating a nonsurgical intervention on osteoarthritis (OA) of any joint9 knee OA studies
- Comparison
- Nonsurgical interventions for OA: potential mediators of effects on pain and physical function
- Outcome
- Mediators of nonsurgical interventions on pain and physical function in knee OA
Methodological detailsmediation analyses of randomised controlled trials, Searched Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials and Scopus
- Mediation analyses of randomised controlled trials
- Searched Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials and Scopus
Main finding
As reported in the abstract
Mediators partially mediating intervention (diet plus exercise, exercise, high-expectation communication) effects on pain and physical function
10
Mediators common to pain and function (reduced weight, increased knee extensor strength, increased self-efficacy)
8
Original publication
How Do Nonsurgical Interventions Improve Pain and Physical Function in People With Osteoarthritis? A Scoping Review of Mediation Analysis Studies. Arthritis Care Res (Hoboken). Published 31 October 2022. doi:10.
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