Serum phospholipids and sphingolipids are linked to early-stage osteoarthritis by lipidomic profiling
Authors' conclusion
The significant lipidomic alterations that were detected at an average Outerbridge score of less than 2 suggest that certain serum PLs may serve as indicators for monitoring the early stages of OA even before radiologic detection is possible.
Study context
- Population
- Joint-healthy donors and early or late osteoarthritis (OA) patients; knee synovial fluid (SF) and serum44 healthy, 58 OA
- Exposure
- Early OA and late OA patients vs joint-healthy donors
- Healthy controlsn = 44reference
- Outcome
- How closely blood lipid levels (phospholipids (PLs) and SLs) reflect changes in SF
Methodological detailslipidomic profiling, ESI-MS/MS
- Lipidomic profiling
- ESI-MS/MS
Main finding
As reported in the abstract
Serum and SF PL and SL levels
Serum PL and SL levels higher than in SF (times)
3-12
PL species higher exclusively in serum of OA patients
nearly 10%
Observational data: associations, not effects.
Original publication
Serum phospholipids and sphingolipids are linked to early-stage osteoarthritis by lipidomic profiling. Arthritis Res Ther. Published 31 March 2025. doi:10.
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