Impaired Efferocytosis by Synovial Macrophages in Patients With Knee Osteoarthritis
Authors' conclusion
Apoptotic cells accumulate in the synovium of patients with late-stage knee OA. Our results suggest that OA impairs critical homeostatic functions of synovial macrophages, leading to accumulation of apoptotic cells.
Study context
- Population
- Individuals with healthy knees and patients with late-stage knee osteoarthritis (OA) (synovial tissue); synovial fluid also from early-stage knee OA
- Comparison
- Late-stage knee OA vs healthy knees
- Outcome
- Synovial apoptotic cell burden (cleaved caspase 3) and macrophage efferocytosis of apoptotic cells
Main finding
As reported in the abstract
- More apoptotic synovial cells in late-stage knee OA vs healthy individuals
- Marked reduction in fraction of synovial tissue macrophages engaging in efferocytosis and quantity efferocytosed per macrophage in OA
- Blood-derived macrophages exposed to OA synovial fluid recapitulated defective efferocytosis, greatest with early-stage knee OA and higher disease activity (pain and inflammation)
Original publication
Impaired Efferocytosis by Synovial Macrophages in Patients With Knee Osteoarthritis. Arthritis Rheumatol. Published 7 March 2023. doi:10.
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