Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in osteoarthritis (OA)
Authors' conclusion
Our findings support the possible beneficial effects of metformin on improving pain, ADL, Sport/Rec, and QOL in OA patients. Our findings support the association between the CC genotype of Bcl-2 and GG+GA genotypes of CXCL-16 and OA.
Study context
- Population
- Overweight patients with knee OA
- Participants
- 44 / 44 / 92
- Comparison
- Metformin for 4 months vs identical inert placebo
- Metforminn = 44
- Placebon = 44reference
- Healthy individualsn = 92
- Primary endpoint
- KOOS questionnaire scores
- Follow-up
- 4 months
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
KOOS scores, metformin vs placebo
- Increase in total KOOS scores with metformin vs placebo
- Metformin vs Placebo: P ≤ 0.0001
- Metformin vs Placebo: P ≤ 0.0001
- Metformin vs Placebo: P ≤ 0.0001
- Metformin vs Placebo: P = 0.003
Further findings
OA susceptibility: CC genotype of 938C>A (Bcl-2 rs2279115)
| OR (95% CI) | P value | ||
|---|---|---|---|
| CC genotype | 5.2 (2.0–13.7) | Pa = 0.001 | |
| 0.050.21520Odds ratio (log scale) |
OA susceptibility: GG+GA genotypes of A181V (CXCL-16 rs2277680)
| OR (95% CI) | P value | ||
|---|---|---|---|
| GG+GA genotypes | 2.1 (1.1–10.5) | Pa = 0.04 | |
| 0.050.21520Odds ratio (log scale) |
OA susceptibility: C allele of 938C>A
| OR (95% CI) | P value | ||
|---|---|---|---|
| C allele | 2.2 (1.1–9.8) | Pa = 0.04 | |
| 0.10.31310Odds ratio (log scale) |
OA susceptibility: G allele of A181V
| OR (95% CI) | P value | ||
|---|---|---|---|
| G allele | 2.2 (1.1–4.8) | Pa = 0.02 | |
| 0.20.5125Odds ratio (log scale) |
OA susceptibility associated with age, gender, family history
- Susceptibility to OA was associated with age, gender, family history
Original publication
Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA. Arthritis Res Ther. Published 7 March 2023. doi:10.
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