Quantitative infrapatellar fat pad signal intensity alteration as an imaging biomarker of knee osteoarthritis progression
Main finding · Clinically relevant progression (radiographic and pain), baseline Clustering factor (H)Result — go to the resultOdds ratio 1.22Authors' conclusion
The associations of short-term alteration in quantitative IPFP signal intensity measures with long-term knee OA progression suggest that these measures might serve as efficacy of intervention biomarkers of knee OA.
Study context
- Population
- Participants of the Foundation for the National Institutes of Health Osteoarthritis (OA) Biomarkers Consortium study (knee OA)
- Participants
- 600 participants
- Comparison
- Quantitative infrapatellar fat pad (IPFP) signal intensity measures (baseline and time-integrated over 12 and 24 months) vs knee OA progression over 48 months
- Outcome
- Clinically relevant knee OA progression (both radiographic and pain progression)
- Follow-up
- 48 months
Methodological detailsFoundation for the National Institutes of Health OA Biomarkers Consortium, adjusted for baseline confounders
- Foundation for the National Institutes of Health OA Biomarkers Consortium
- Adjusted for baseline confounders
Main finding
As reported in the abstract
Clinically relevant progression (radiographic and pain), baseline Clustering factor (H)
Odds ratio
1.22
Observational data: associations, not effects.
Further findings
Clinically relevant progression, time-integrated IPFP signal intensity measures over 24 months (all except Mean (IPFP))
- Positively associated with clinically relevant progression; ORs ranging from
- 1.23 to 1.39
Clinically relevant progression, time-integrated IPFP signal intensity measures over 12 months (all except Mean (IPFP) and Mean (H))
- Positively associated with clinically relevant progression; ORs ranging from
- 1.20 to 1.31
Radiographic vs pain progression, examined separately
- More IPFP signal intensity measures with stronger effect sizes associated with radiographic progression than with pain progression
Original publication
Quantitative infrapatellar fat pad signal intensity alteration as an imaging biomarker of knee osteoarthritis progression. RMD Open. Published 25 January 2023. doi:10.
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