Selection of Knees With Subsequent Cartilage Thickness Loss Based on Magnetic Resonance Imaging Semiquantitative Grading: Data From the Osteoarthritis Initiative Foundation for the National Institutes of Health Biomarker Cohort
Authors' conclusion
MRI-based grading of articular pathologies makes it possible to specifically select progressor knees suitable for inclusion in clinical trials but also to identify knees in which treatment is not indicated (e.g., knees without cartilage damage despite presence of radiographic osteoarthritis).
Study context
- Population
- Participants of the OA Initiative-based Foundation for the National Institutes of Health OA Biomarkers Consortium (age 62 years; BMI 31 kg/m²; 59% female)
- Participants
- 599 participants
- Exposure
- Knees with vs without baseline medial femorotibial compartment (MFTC) MRI Osteoarthritis Knee Score (MOAKS) pathologies
- Outcome
- MFTC progression (cartilage thickness change beyond smallest detectable change threshold −111 μm)
- Follow-up
- Year-2
Methodological detailslogistic regression, standardized response mean
- Logistic regression
- Standardized response mean
Main finding
As reported in the abstract
Presence of MFTC MOAKS cartilage damage associated with subsequent progression, OR
2.77 (1.76, 4.36) (95% CI)
Presence of MFTC bone marrow lesions associated with subsequent progression, OR
2.69 (1.89, 3.83) (95% CI)
Presence of medial meniscus extrusion or damage associated with subsequent progression, OR
2.21 (1.37, 3.55) (95% CI)
Observational data: associations, not effects.
Further findings
Standardized response mean (SRM) (sensitivity to change)
- SRM greater in knees with than without these pathologies and associated with their severity
Original publication
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