Association of physical activity with loss of knee joint space width over two years: a compositional data analysis in the Osteoarthritis Initiative
Authors' conclusion
Using CoDA, PA composition was not associated with medial JSW loss over 2 years.
Study context
- Population
- Subset of Osteoarthritis Initiative participants with 7-day minute-by-minute activity data at baseline (age 64.5 years, 56% female, BMI 28.8 kg/m²)
- Participants
- 969 participants
- Comparison
- Physical activity (PA) composition and medial knee joint space width (JSW) loss
- Primary endpoint
- Medial JSW loss: difference in medial tibiofemoral JSW from baseline to 2 years
- Follow-up
- 2 years
Methodological detailscompositional data analysis, isometric log-ratio transformation, adjusted regression
- Compositional data analysis
- Isometric log-ratio transformation
- Adjusted regression
Primary result
As reported in the abstract
Association of PA composition with medial JSW loss (adjusted regression)
- Higher moderate-to-vigorous PA (MVPA), β
- −0.0005, P = 0.97
- Light PA (LPA), β
- 0.06, P = 0.27
- SED, β
- −0.06, P = 0.21
- Mean PA composition: MVPA (min/day)
- 9.1
- Mean PA composition: LPA (min/day)
- 278
- Mean PA composition: SED (min/day)
- 690
Original publication
Association of physical activity with loss of knee joint space width over two years: a compositional data analysis in the Osteoarthritis Initiative. Osteoarthritis Cartilage. Published 21 February 2023. doi:10.
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