Association of accelerometer-measured physical activity patterns with cardiovascular diseases and mortality in people with osteoarthritis
Authors' conclusion
Engaging in a weekend warrior pattern may confer unique survival benefits for OA patients, especially among older adults and those with obesity. LPA may have dose-dependent protective effects for CVD and mortality risk in OA patients.
Study context
- Population
- Osteoarthritis (OA) participants from the UK biobank with ≥36 h of accelerometer data collected over one week (mean age 58.1 ± 7.1 years; 64.5% female)
- Participants
- 10,210 participants
- Exposure
- Weekend warrior and active regular moderate to vigorous physical activity (MVPA) patterns vs inactive MVPA; Light physical activity (LPA) quartiles
- Outcome
- Incident CVD, CVD-cause mortality and all-cause mortality
- Follow-up
- Median 6.9 years
Methodological detailsUK Biobank, accelerometer-measured physical activity
- UK Biobank
- Accelerometer-measured physical activity
Main finding
As reported in the abstract
Incident CVD
Each group vs inactiveAdjusted hazard ratio (95% CI)
Weekend warriors
0.73(0.64–0.82)
Active regular
0.75(0.65–0.87)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| CVD-cause mortalityWeekend warriorsvs Inactive | 0.55 (0.33–0.92) | |
| All-cause mortalityWeekend warriorsvs Inactive | 0.75 (0.59–0.96) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- Cardiovascular diseases (CVD)-cause mortality — Deaths from CVD
- 90
- All-cause mortality — Deaths
- 358
CVD-cause mortality
- Only the weekend warrior group showed significant reductions
LPA quartiles
- Higher LPA may link to lower CVD, CVD-cause mortality and all-cause mortality risks in a dose-response manner
Subgroups
- More prominent associations in individuals with BMI >30 or aged over 60
Original publication
Association of accelerometer-measured physical activity patterns with cardiovascular diseases and mortality in people with osteoarthritis. Rheumatology (Oxford). Published 13 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →