Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis
Authors' conclusion
The association of higher vitamin K intake with decreased knee symptoms over 24 months in patients with knee OA suggests that clinical trials examining the effect of vitamin K supplementation for knee OA symptoms are warranted. Whether there is an effect on knee structure is unclear.
Study context
- Population
- Participants with symptomatic knee osteoarthritis (OA)212 followed up for 2 years
- Participants
- 259 participants
- Exposure
- Quartiles of baseline dietary vitamin K intake
- Outcome
- Changes in knee symptoms (WOMAC) and structures (cartilage defects, bone marrow lesions, effusion-synovitis volume on MRI)
- Follow-up
- 24 months
Methodological detailsunivariable and multivariable linear regression
- Univariable and multivariable linear regression
Main finding
As reported in the abstract
Change in WOMAC scores
- Higher vitamin K intake quartile significantly associated with greater decrease in total WOMAC score and dysfunction score
Observational data: associations, not effects.
Further findings
Change in magnetic resonance imaging (MRI) features · 24 months
- No overall significant associations between vitamin K intake and changes in MRI features
Change in WOMAC scores in severe baseline visual analog scale (VAS) pain (subgroup) · 24 months
- Higher vitamin K intake quartile associated with more improvement in all WOMAC scores
Change in cartilage defects (subgroups) · 24 months
- Vitamin K intake negatively associated with changes in tibiofemoral, patellar and total cartilage defects in severe baseline radiographic grade
- Vitamin K intake negatively associated with change in total and patellar cartilage defects in severe baseline VAS pain and in female patients
Original publication
Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis. Arthritis Care Res (Hoboken). Published 20 February 2023. doi:10.
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