Metabolic syndrome and the progression of knee osteoarthritis on magnetic resonance imaging (MRI)
Authors' conclusion
Women with higher MetS severity at baseline showed progression of osteophytes, BMLs, and cartilage defects, indicating more structural knee OA progression after 5 years.
Study context
- Population
- Women from the Rotterdam Study with knee MRI data and 5-year follow-up
- Participants
- 682 women
- Exposure
- Metabolic syndrome (MetS) severity and its components vs progression of knee osteoarthritis (OA) MRI features
- Outcome
- Progression of knee OA MRI features (TF and PF, MRI Osteoarthritis Knee Score)
- Follow-up
- 5 years
Methodological detailspopulation-based (Rotterdam Study sub-study), 5-year follow-up, generalized estimating equations
- Population-based (Rotterdam Study sub-study)
- 5-year follow-up
- Generalized estimating equations
Main finding
As reported in the abstract
Association of baseline MetS severity with progression of MRI features
- MetS severity associated with progression of osteophytes in all compartments
- MetS severity associated with progression of bone marrow lesions (BMLs) in the patellofemoral (PF) compartment
- MetS severity associated with progression of cartilage defects in the medial tibiofemoral (TF) compartment
Observational data: associations, not effects.
Further findings
MetS components
- Waist circumference associated with progression of osteophytes in all compartments and cartilage defects in the medial TF compartment
- High-density lipoprotein (HDL)-cholesterol associated with progression of osteophytes in the medial and lateral TF compartment
- Glucose associated with osteophytes in the PF and medial TF compartment
Interaction of MetS with menopausal transition
- No interactions found between MetS with menopausal transition and MRI features
Original publication
Metabolic syndrome and the progression of knee osteoarthritis on MRI. Osteoarthritis Cartilage. Published 16 February 2023. doi:10.
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