Metabolic syndrome, radiographic osteoarthritis progression and chronic pain of the knee among men and women from the general population: The Rotterdam study
Authors' conclusion
Metabolic syndrome and individual metabolic components, such as abdominal obesity and elevated blood pressure, were associated with radiographic progression of knee OA in both men and women, but not independent of BMI. Metabolic syndrome and high triglycerides were associated with incidence of CKP only in men.
Study context
- Population
- Men and women from the general population, Rotterdam study; median follow-up 5.7 (IQR 5.5) yearsup to 6,138
- Participants
- 6,138 men
- Exposure
- Metabolic syndrome (MetS) and its components vs their absence
- Outcome
- Progression of radiographic knee OA and incident chronic knee pain (CKP)
Methodological detailspopulation-based, stratified by sex, generalized estimating equations, generalized linear models and competing risk analysis
- Population-based
- Stratified by sex
- Generalized estimating equations, generalized linear models and competing risk analysis
Main finding
As reported in the abstract
Radiographic knee OA progression
- MetS and elevated blood pressure associated with increased risk of knee OA progression in both men and women
- Associations attenuated and no longer significant after BMI adjustment
Observational data: associations, not effects.
Further findings
| Outcome | OR (95 % CI) | |
|---|---|---|
| Incident CKP in men, BMI-adjustedMetSvs No MetSMen | 1.04 (1.00–1.07) | |
| 0.512Odds ratio (log scale) |
Incident chronic knee pain (CKP) in men, BMI-adjusted
| OR (95 % CI) | ||
|---|---|---|
| High triglyceridesMen | 1.04 (1.01–1.07) | |
| 0.512Odds ratio (log scale) |
- MetS, abdominal obesity and high triglycerides associated with higher risk of incident CKP in men, not in women
Prevalence of MetS
%
- Men
- 37.6
- Women
- 39
Original publication
Metabolic syndrome, radiographic osteoarthritis progression and chronic pain of the knee among men and women from the general population: The Rotterdam study. Semin Arthritis Rheum. Published 7 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →