Evidence-based hierarchy of pain outcome measures for osteoarthritis clinical trials and meta-analyses
Authors' conclusion
Pain overall has better assay sensitivity than other pain PROMs.
Study context
- Population
- Trials with placebo, sham, or non-intervention control, ≥100 patients per arm with knee/hip OA, reporting effects on ≥2 pain patient-reported outcome measures (PROMs)
- Participants
- 57,141 participants135 trials
- Comparison
- Pain PROMs ranked by assay sensitivity
- Outcome
- Assay sensitivity of pain PROMs (ability to distinguish an effective from a less effective intervention or placebo); negative MDs indicate larger effect of experimental treatment
Methodological detailsrandom-effects model, treatment effects standardized on a 0-100 scale
- Random-effects model
- Treatment effects standardized on a 0-100 scale
Main finding
As reported in the abstract
Ranking of PROMs by assay sensitivity, highest to lowest: pain overall, pain on stairs, pain at night, pain on walking, pain at rest, WOMAC pain, WOMAC global, Lequesne index
Pooled ratio of mean differences
1.42
95% CrI 1.30–1.55
By group
Pain overall
−6.96
pooled mean difference · 95% CrI −7.94–-6.02
WOMAC pain
−4.90
pooled mean difference · 95% CrI −5.55–-4.26
Original publication
Evidence-based hierarchy of pain outcome measures for osteoarthritis clinical trials and meta-analyses. Osteoarthritis Cartilage. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →