Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD)
Authors' conclusion
Different standardised PROMs give similar PASS thresholds in group data.
Study context
- Population
- People with knee pain due to OA or knee trauma
- Participants
- 6,339 people18 studies
- Comparison
- Standardised knee pain patient-reported outcome measures (PROMs) compared via PASS scores
- Outcome
- Pooled standardised PASS (0–100, worst) across knee pain PROMs
Methodological detailsmeta-regression, Bland Altman plots
- Meta-regression
- Bland Altman plots
Pooled result
As reported in the abstract
Pooled standardised PASS (0–100)
Pooled standardised PASS
27
95% CI 21 to 35
Further pooled results
Associations of PASS (meta-regression)
- Lower PASS associated with lower baseline pain
- β = 0.49, P = 0.01
- Lower PASS associated with longer time from treatment initiation
- Q = 6.35, P = 0.04
PASS by condition
- Ligament rupture (lowest)
- 12, 95% CI: 11 to 13
- Knee OA
- 31, 95% CI: 26 to 36
- Meniscal tear
- 27, 95% CI: 20 to 35
- Similar between knee OA and meniscal tear
Within-individual agreement between PROMs (IPD, Bland Altman)
- Scores within individuals diverged between PROMs (LoA)
- between −7 to −38 and +25 to 52
- Similar group mean scores across standardised PROMs
- IPD from WebEx, KICK, MenTOR and NEKO studies
Original publication
Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD). Osteoarthritis Cartilage. Published 8 September 2022. doi:10.
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