Who are likely to benefit from the Good Life with osteoArthritis in Denmark (GLAD) exercise and education program? An effect modifier analysis of a randomised controlled trial
Authors' conclusion
These results imply that patients who take analgesics or report constant knee pain, GLAD seems to yield clinically relevant benefits on knee pain when compared to OLP.
Study context
- Population
- Participants with symptomatic and radiographic knee osteoarthritis (OA)
- Participants
- 206 participants
- Comparison
- 8-week GLAD exercise and education programme vs open-label placebo (OLP)
- GLADn = 102
- OLPn = 104reference
- Primary endpoint
- Change in KOOS pain subscale (0 worst to 100 best)
- Follow-up
- Week 9
Methodological detailseffect modifier analysis, subgroup analysis
- Effect modifier analysis
- Subgroup analysis
Primary result
As reported in the abstract
KOOS pain change, subgroup contrasts (GLAD vs OLP)
Subgroup contrast (baseline analgesic use)
10.3 KOOS pain points
95% CI 3.0–17.6
participants using analgesics at baseline
Subgroup contrast (constant pain at baseline)
10.0 points
95% CI 2.8–17.2
participants with constant pain at baseline
Original publication
Who are likely to benefit from the Good Life with osteoArthritis in Denmark (GLAD) exercise and education program? An effect modifier analysis of a randomised controlled trial. Osteoarthritis Cartilage. Published 8 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →