Efficacy and Safety of Tramadol for Knee or Hip Osteoarthritis: A Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials
Authors' conclusion
Only tramadol 300 mg/day showed minimal improvement in pain and function but with increasing AEs compared with placebo.
Study context
- Population
- Randomized Controlled Trials (RCTs) in knee or hip Osteoarthritis (OA); PubMed, Embase, Cochrane Library and Web of Science searched to May 2020
- Participants
- 3,611 participants6 RCTs
- Comparison
- Tramadol 100, 200 and 300 mg/day vs placebo
- Outcome
- Efficacy: pain and function
- Follow-up
- At or near 12 weeks
Methodological detailsBayesian network meta-analysis
- Bayesian network meta-analysis
Pooled result
As reported in the abstract
Pain relief
Each group vs placeboSMD (95% CI)
Tramadol 100 mg/day
−0.16(−0.34 to 0.00)
Tramadol 200 mg/day
−0.21(−0.37 to −0.06)
Tramadol 300 mg/day
−0.30(−0.48 to −0.14)
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| Functional improvement · at or near 12 weeksTramadol 300 mg/dayvs Placebo | −0.24 (−0.47 to −0.03) | |
| −0.6−0.4−0.200.2Difference (linear scale) |
Functional improvement · at or near 12 weeks
- Only tramadol 300 mg/day was better than placebo in functional improvement
Safety
| Outcome | RR (95% CrI) | |
|---|---|---|
| Gastrointestinal AEsTramadol 100 mg/dayvs PlaceboCrI | 2.29 (1.22–4.25) | |
| Gastrointestinal AEsTramadol 200 mg/dayvs PlaceboCrI | 4.35 (2.31–8.01) | |
| Gastrointestinal AEsTramadol 300 mg/dayvs PlaceboCrI | 6.02 (3.22–11.1) | |
| 0.050.21520Relative risk (log scale) |
CNS adverse events (AEs) and withdrawals
- Tramadol 100-300 mg/day showed a higher risk of CNS AEs and withdrawals
Cardiovascular AEs
- Risk of cardiovascular AEs remained unclear
Original publication
Efficacy and Safety of Tramadol for Knee or Hip Osteoarthritis: A Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials. Arthritis Care Res (Hoboken). Published 23 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →