Association between popliteal artery wall thickness and structural progression in patients with symptomatic knee osteoarthritis
Authors' conclusion
The findings support a role for vascular pathology in the progression of knee OA.
Study context
- Population
- Individuals with symptomatic knee OA in a randomised placebo-controlled trial of atorvastatin
- Participants
- 176 individuals
- Exposure
- Per 10% increase in popliteal artery wall thickness
- Outcome
- Association between popliteal artery wall thickness and tibial cartilage volume (MRI)
- Follow-up
- 2-year follow-up
Methodological detailsanalysis of a randomised placebo-controlled trial of atorvastatin, MRI at baseline and 2-year follow-up
- Analysis of a randomised placebo-controlled trial of atorvastatin
- MRI at baseline and 2-year follow-up
Main finding
As reported in the abstract
Tibial cartilage volume per 10% increase in popliteal artery wall thickness
Baseline medial tibial cartilage volume, lower by
120.8
mm³; 95% CI 5.4, 236.2P = 0.04
Baseline lateral tibial cartilage volume, lower by
151.9
mm³; 95% CI 12.1, 291.7P = 0.03
Annual rate of medial tibial cartilage volume loss, increased by
1.14%
95% CI 0.09%, 2.20%P = 0.03
Risk of rapid progression (top quartile of loss rate) of medial tibial cartilage loss, fold
2.28
95% CI 1.07, 4.83P = 0.03
Observational data: associations, not effects.
Original publication
Association between popliteal artery wall thickness and structural progression in patients with symptomatic knee osteoarthritis. Rheumatology (Oxford). Published 16 August 2022. doi:10.
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