Serum biomarkers in prednisolone-treated hand osteoarthritis patients
Authors' conclusion
Erosive disease was associated with higher levels of C1M and hsCRP. Biomarker levels were not influenced by treatment with prednisolone. Current biomarkers were not associated with response to prednisolone in hand OA.
Study context
- Population
- Patients with painful inflammatory hand OA (mean age 64 years, 79% female)
- Participants
- 78 patients
- Comparison
- Prednisolone vs placebo
- Primary endpoint
- Modulation of serum biomarkers (ARGS, C1M, C3M, PROC5, CRPM, VICM, hsCRP) by prednisolone and their prediction of OMERACT-OARSI response
- Follow-up
- 6 weeks
Methodological detailsplacebo-controlled, biomarker analysis
- Placebo-controlled
- Biomarker analysis
Primary result
As reported in the abstract
No association between baseline biomarker levels and OARSI response, except CRPM (geometric mean ratio)
0.88
0.77, 1.00
Further findings
Baseline biomarkers in erosive hand OA (adjusted geometric mean ratio)
- C1M
- 1.24 (95% CI 1.03, 1.49)
- hsCRP
- 1.91 (1.19, 3.06)
- Adjusted for age, BMI and sex
Baseline biomarkers vs visual analogue scale (VAS) finger pain or synovial thickening score
- No associations
Original publication
Serum biomarkers in prednisolone-treated hand osteoarthritis patients. Rheumatology (Oxford). Published 10 August 2022. doi:10.
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