Synovitis scoring in hand osteoarthritis with ultrasonography: the performance of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) is comparable to synovial thickening alone
Authors' conclusion
The GLOESS and synovial thickening were both responsive to treatment, but GLOESS was not superior to synovial thickening alone.
Study context
- Population
- Patients with painful, inflammatory hand OA in the HOPE trial; ultrasound of 30 hand joints at weeks 0, 6 and 1479% women
- Participants
- 92 patients
- Comparison
- Prednisolone vs placebo; ultrasound synovitis scores
Methodological detailsdouble-blinded, Generalised estimating equations; effect sizes calculated
- Double-blinded
- Generalised estimating equations; effect sizes calculated
Primary result
As reported in the abstract
Responsiveness of US scores to treatment (prednisolone vs placebo)
- All US scores strongly associated with joint tenderness and soft swelling cross-sectionally
- No association of change in US scores with change in tenderness, but there was with change in soft tissue swelling
- GLOESS not superior to synovial thickening alone
Further findings
- Synovial thickening was the most prevalent
- All ultrasound scores strongly associated with joint tenderness and soft swelling cross-sectionally
- No association of change in ultrasound scores with change in tenderness
- Change in ultrasound scores associated with change in soft tissue swelling
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Synovitis scoring in hand osteoarthritis with ultrasonography: the performance of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) is comparable to synovial thickening alone. RMD Open. Published 31 December 2024. doi:10.
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