National Institute of Health and Care Excellence Clinical Criteria for the Diagnosis of Knee Osteoarthritis: A Prospective Diagnostic Accuracy Study in Individuals With Type 2 Diabetes
Authors' conclusion
The NICE criteria have high sensitivity and specificity for detecting symptomatic knee OA in a population with type 2 diabetes. We found that a modified version, omitting the stiffness criterion, performed similarly.
Study context
- Population
- Individuals with type 2 diabetes with and without self-reported knee pain, within a larger studymean age 65.4 years
- Participants
- 96 individuals
- Comparison
- NICE criteria and modified NICE criteria (without stiffness criterion) by questionnaire vs rheumatologist clinical evaluation (reference standard)
- Outcome
- Sensitivity, specificity, LR+ and LR- of the NICE criteria for symptomatic knee OA
Methodological detailsprospective
- Prospective
Performance
As reported in the abstract
Diagnostic accuracy for symptomatic knee OA
| Test or model | Sensitivity | Specificity | LR+ | LR- |
|---|---|---|---|---|
| NICE criteria | 0.84 (95% CI 0.74-0.94) | 0.85 (95% CI 0.74-0.96) | 5.6 | 0.19 |
| Modified NICE criteria | 0.89 (95% CI 0.82-0.97) | 0.85 (95% CI 0.74-0.96) | 5.93 | 0.13 |
Sensitivity
NICE criteria0.84 (95% CI 0.74-0.94)
Modified NICE criteria0.89 (95% CI 0.82-0.97)
Specificity
NICE criteria0.85 (95% CI 0.74-0.96)
Modified NICE criteria0.85 (95% CI 0.74-0.96)
LR+
NICE criteria5.6
Modified NICE criteria5.93
LR-
NICE criteria0.19
Modified NICE criteria0.13
Further findings
- Symptomatic knee osteoarthritis (OA) by rheumatologist assessment (prevalence)
- 58.3% · 56 events
- Fulfilled NICE criteria; pain NRS (11-point) among them
- 55.2%
Original publication
National Institute of Health and Care Excellence Clinical Criteria for the Diagnosis of Knee Osteoarthritis: A Prospective Diagnostic Accuracy Study in Individuals With Type 2 Diabetes. Arthritis Care Res (Hoboken). Published 29 December 2024. doi:10.
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