Association Between Symptomatic Knee Osteoarthritis and Target Glycemic Control in Individuals With Type 2 Diabetes
Authors' conclusion
Individuals with T2DM and painful knee OA are less likely to be at glycemic target, increasing their risk of diabetes complications.
Study context
- Population
- Individuals with T2DM aged ≥45 years, three academic centers in Canada (mean age 66.2 years, 50.7% women)28.5% with knee osteoarthritis (OA)
- Participants
- 351 individuals
- Exposure
- Symptomatic knee OA vs no knee OA
- Outcome
- Target glycemic control (HbA1c ≤7.0%)
Methodological detailsmulticentre, multivariable logistic regression adjusted for age, gender, education level and BMI
- Multicentre
- Multivariable logistic regression adjusted for age, gender, education level and BMI
Main finding
As reported in the abstract
Knee OA vs No knee OAEstimate (95% CI)
After adjusting for confounders
aOR 0.65(0.39–1.08)
Target glycemic control (HbA1c ≤7.0%)
OR (unadjusted) 0.60(0.37–0.97)
- Overall at glycemic target
- 43.9%
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Target glycemic control, knee OA with pain ≥20/100Knee OA with pain ≥20/100vs No knee OAStatistically significant in adjusted analysis | 0.58 (0.34–0.99) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Original publication
Association Between Symptomatic Knee Osteoarthritis and Target Glycemic Control in Individuals With Type 2 Diabetes. Arthritis Care Res (Hoboken). Published 28 March 2026. doi:10.
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