Subchondral bone marrow adipose tissue lipolysis regulates bone formation in hand osteoarthritis
Authors' conclusion
Our findings reveal a previously unrecognized role of BMAT lipolysis in regulating bone formation in hand OA, which may be modulated by BMI.
Study context
- Population
- Clinical specimens of CMC-1 and distal interphalangeal joint hand osteoarthritis (OA)
- Comparison
- Regions of high vs low subchondral bone formation
- Outcome
- Subchondral bone marrow adipose tissue (BMAT) lipolysis and BMAd morphology vs bone formation
Methodological detailsclinical specimens, osteochondral explants
- Clinical specimens
- Osteochondral explants
Main finding
As reported in the abstract
- Bone marrow adipocyte (BMAd) size correlated with BMI (r, [CI])
- r = 0.60, [0.082,0.87]
- BMAd size reduced in regions of high bone formation
- −1149 µm², [−1977,−726.2]
- Osteoblast numbers negatively correlated with BMAd size
- r = −0.48, [−0.73,−0.12]
- ATGL area percentage increased in regions of high bone formation
- +2.26% [0.19,3.47]
- Phospho-HSL area percentage increased in regions of high bone formation
- +1.57% [0.31,6.48]
- MGLL area percentage increased in regions of high bone formation
- +4.04% [1.09,5.69]
- Secreted glycerol correlated with pro-collagen type I
- rho = 0.90
- Secreted glycerol correlated with alkaline phosphatase
- rho = 0.78
Original publication
Subchondral bone marrow adipose tissue lipolysis regulates bone formation in hand osteoarthritis. Osteoarthritis Cartilage. Published 24 December 2024. doi:10.
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