Neuropathic Pain Associated With First Metatarsophalangeal Joint Osteoarthritis: Frequency and Associated Factors
Authors' conclusion
A significant proportion of individuals with first MTP joint OA report symptoms suggestive of neuropathic pain, which may partly explain the suboptimal responses to commonly used treatments for this condition.
Study context
- Population
- People with symptomatic radiographic first metatarsophalangeal (MTP) joint osteoarthritis (OA) (mean ± SD age 57.4 ± 10.3 years)
- Participants
- 98 people
- Exposure
- Possible/likely neuropathic pain vs unlikely neuropathic pain
- Possible/likely neuropathic painn = 30
- Outcome
- Likelihood of neuropathic pain (PainDETECT questionnaire cutoff points)
Main finding
As reported in the abstract
Possible/likely neuropathic pain (PD-Q)
Possible/likely neuropathic pain
30
31%
Possible neuropathic pain
19
19.4%
Likely neuropathic pain
11
11.2%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Factors associated with possible/likely vs unlikely neuropathic pain (effect size, Cohen's d)Possible/likely neuropathic pain vs Unlikely neuropathic pain | Cohen's d, older age 0.59 | P = 0.010 |
| Factors associated with possible/likely vs unlikely neuropathic pain (effect size, Cohen's d)Possible/likely neuropathic pain vs Unlikely neuropathic pain | Cohen's d, worse SF-12 physical scores 1.10 | P < 0.001 |
| Factors associated with possible/likely vs unlikely neuropathic pain (effect size, Cohen's d)Possible/likely neuropathic pain vs Unlikely neuropathic pain | Cohen's d, worse pain self-efficacy scores 0.98 | P < 0.001 |
| Factors associated with possible/likely vs unlikely neuropathic pain (effect size, Cohen's d)Possible/likely neuropathic pain vs Unlikely neuropathic pain | Cohen's d, worse FHSQ pain scores 0.98 | P < 0.001 |
| Factors associated with possible/likely vs unlikely neuropathic pain (effect size, Cohen's d)Possible/likely neuropathic pain vs Unlikely neuropathic pain | Cohen's d, worse FHSQ function scores 0.82 | P < 0.001 |
| Factors associated with possible/likely vs unlikely neuropathic pain (effect size, Cohen's d)Possible/likely neuropathic pain vs Unlikely neuropathic pain | Cohen's d, higher pain severity at rest 1.01 | P < 0.001 |
Most common neuropathic symptoms
- Sensitivity to pressure
- 56%
- Sudden pain attacks/electric shocks
- 36%
- Burning
- 24%
Original publication
Neuropathic Pain Associated With First Metatarsophalangeal Joint Osteoarthritis: Frequency and Associated Factors. Arthritis Care Res (Hoboken). Published 11 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →