Folate deficiency is associated with increased radiographic severity of osteoarthritis in knee joints but not in hand joints
Authors' conclusion
Folate deficiency is associated with increased radiographic severity of OA in knee joints, but not in hand joints.
Study context
- Population
- Subjects of the population-based Dong-gu study with knee and hand radiographs, excluding amputation or total knee replacementDong-gu study
- Participants
- 2,322 subjects
- Exposure
- Folate deficiency vs normal folate level
- Outcome
- Semi-quantitative knee and hand radiographic osteoarthritis (OA) scores
Methodological detailspopulation-based cohort, linear regression adjusted for confounders
- Population-based cohort
- Linear regression adjusted for confounders
Main finding
As reported in the abstract
Knee radiographic scores (adjusted)
- Folate deficiency vs Normal folate: P < 0.001
- Folate deficiency vs Normal folate: P < 0.001
- Folate deficiency vs Normal folate: P = 0.002
- Folate deficiency vs Normal folate: P < 0.001
- Folate deficiency vs Normal folate: P = 0.005
- Adjusted for age, sex, BMI, smoking, alcohol, education, physical activity, occupation, vitamin D, ferritin
Observational data: associations, not effects.
Further findings
Hand radiographic scores (adjusted)
- Did not differ between the groups
Original publication
Folate deficiency is associated with increased radiographic severity of osteoarthritis in knee joints but not in hand joints. Clin Exp Rheumatol. Published 9 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →