Association of Pain During Exercise With Exercise‐Induced Hypoalgesia in People With Knee Osteoarthritis
Main finding · Subsequent EIHResult — go to the resultOdds ratio 1.43 95% CI 1.05–1.94Authors' conclusion
Our finding suggests that some amount of discomfort or pain during exercise may have beneficial analgesic effects; however, this is not likely via activation of the descending pain inhibitory system.
Study context
- Population
- People with symptomatic knee osteoarthritis (OA) (baseline data from two clinical trials)
- Participants
- 68 people
- Exposure
- At least a one-unit increase in pain with exercise vs no pain increase
- Outcome
- EIH: increase in pressure pain threshold (PPT) after a bout of exercises, by pain evoked during exercise (maximum pain rating 0-10)
Methodological detailsbaseline data from two clinical trials, causal mediation analysis
- Baseline data from two clinical trials
- Causal mediation analysis
Main finding
Subsequent EIH
Odds ratio
1.43
95% CI 1.05–1.94
Pain increasevs No pain increase
OR 1.43 (95% CI 1.05–1.94)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mediation by conditioned pain modulation (CPM) efficiency of the relation between pain during exercise and exercise-induced hypoalgesia (EIH)
- CPM efficiency did not mediate the relationship between pain during exercise and EIH (OR)
- 1.00 (95% CI 0.96-1.04)
Original publication
Association of Pain During Exercise With Exercise‐Induced Hypoalgesia in People With Knee Osteoarthritis. Arthritis Care Res (Hoboken). Published 7 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →