High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm
Primary result · Medial tibiofemoral cartilage thickness, mean change (randomised arm)Result — go to the resultMean between-group difference 0.18 mm 95% CI 0.18–0.19Authors' conclusion
These results support use of medial opening wedge HTO to slow progression of structural joint damage and improve clinical outcomes among patients with medial compartment knee osteoarthritis and varus alignment.
Study context
- Population
- Adults with varus alignment and symptomatic knee OA primarily involving the medial compartment; tertiary care centre71 randomised, 74 preference
- Participants
- 145 adults
- Comparison
- Nonsurgical management plus medial opening wedge high tibial osteotomy (HTO) vs nonsurgical management alone
- Primary endpoint
- Change in medial tibiofemoral articular cartilage thickness on masked 3-Tesla MRI (6.3% loss = minimal clinically important difference (MCID))
- Follow-up
- 2 years
Methodological detailssingle-centre, open-label, assessor-blinded, parallel preference arm, Limitation: single-centre study
- Single-centre
- Open-label
- Assessor-blinded
- Parallel preference arm
- Limitation: single-centre study
Primary result
As reported in the abstract
Medial tibiofemoral cartilage thickness, mean change (randomised arm)
Mean between-group difference
0.18 mm
95% CI 0.18–0.19
Change by group
HTO
−0.07
mean · mm
Control
−0.25
mean · mm
HTOvs Control
mean between-group difference 0.18 mm (95% CI 0.18–0.19)
Secondary outcomes
Points
| Outcome | HTO | Control | Mean difference (points) (CI) | |
|---|---|---|---|---|
| Total KOOS (0-100; MCID 10 points), change (randomised arm) · 2 yearsKey secondary outcome | 24.95 | 9.06 | 15.89 (8.94–22.84) | |
| −100102030Difference, points (linear scale) |
Cartilage thickness and KOOS (preference arm) · 2 years
- These outcomes also favored HTO in the preference arm
- 65 of 74 (88%; 36 HTO, 29 control) assessed
Original publication
High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm. Ann Intern Med. Published 29 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →