Prevalence of neuropathic-like pain phenotype in people with hand osteoarthritis: A systematic literature review and meta-analysis
Authors' conclusion
These patients often experience neuropathic pain, which may indicate a more painful and disabling condition involving specific neurophysiological abnormalities.
Study context
- Population
- People with hand OA (hand osteoarthritis (HOA)); studies in PubMed, Embase, Web of Science and Cochrane Library up to 12 February 2025
- Participants
- 1,084 people8 studies
- Comparison
- HOA patients with NP vs without NP
- HOA with NPn = 409
- Outcome
- Prevalence of neuropathic-like pain (NP) in HOA
Methodological detailsmeta-proportion analysis, inverse of variance method, standardized mean differences
- Meta-proportion analysis
- Inverse of variance method
- Standardized mean differences
Pooled result
As reported in the abstract
Prevalence of NP in HOA
HOA with NP
42.2%
409
Further pooled results
Pain intensity · significantly greater pain intensity with NP
P < 0.001
| Outcome | HOA with NP | HOA without NP | P value |
|---|---|---|---|
| FIHOA scoreHigher with NP, not statistically significant | 12.9 ± 6.9 | 11.9 ± 7.2 | P = 0.19 |
Age
- HOA patients with NP were younger
Sex, BMI, CRP, erosive disease
- No differences between patients with and without NP
Original publication
Prevalence of neuropathic-like pain phenotype in people with hand osteoarthritis: A systematic literature review and meta-analysis. Joint Bone Spine. Published 24 November 2025. doi:10.
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