Exercise and education vs intra-articular saline for knee osteoarthritis: a 1-year follow-up of a randomized trial
Primary result · KOOS pain, mean change from baselineResult — go to the resultDifference 1.5 points 95% CI −2.6 to 5.5Authors' conclusion
In this 1-year follow-up of individuals with knee OA, the 8-week GLAD program and OLP both provided minor longer-term benefits with no group difference.
Study context
- Population
- Patients with symptomatic and radiographically confirmed knee osteoarthritis (OA)137 provided data at 1 year
- Participants
- 206 patients
- Comparison
- 8-week GLAD exercise and education program vs open-label placebo (OLP)
- GLADn = 102
- OLPn = 104reference
- Primary endpoint
- Change from baseline in KOOS pain subscale
- Follow-up
- 1 year
Methodological details1-year follow-up, open-label
- 1-year follow-up
- Open-label
Primary result
KOOS pain, mean change from baseline
Difference
1.5 points
95% CI −2.6 to 5.5
Change by group
GLAD
8.4
mean
OLP
7.0
mean
GLADvs OLP
Difference 1.5 points (95% CI −2.6 to 5.5)
As reported in the abstract
Secondary outcomes
Key secondary outcomes (KOOS function and quality of life subscales, Patients' Global Assessment of disease impact)
- No between-group differences in any of the secondary outcomes
Original publication
Exercise and education vs intra-articular saline for knee osteoarthritis: a 1-year follow-up of a randomized trial. Osteoarthritis Cartilage. Published 16 January 2023. doi:10.
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