Hysterectomy and risk of osteoarthritis in women: a nationwide nested case–control study
Main finding · OA, hysterectomy vs no hysterectomyResult — go to the resultAdjusted odds ratio 1.19 95% CI 1.09–1.30Authors' conclusion
Our findings indicate that hysterectomy is associated with OA, especially knee OA.
Study context
- Population
- Women in the Taiwan National Health Insurance programme database, 2000 to 2016
- Participants
- 16,592 vs 66,368
- Exposure
- Hysterectomy vs no hysterectomy
- Osteoarthritis (OA)n = 16,592
- Matched controlsn = 66,368reference
- Outcome
- Association between hysterectomy and risk of OA
Methodological detailspopulation-based, nationwide, matched controls, multiple conditional logistic regression
- Population-based
- Nationwide
- Matched controls
- Multiple conditional logistic regression
Main finding
OA, hysterectomy vs no hysterectomy
Adjusted odds ratio
1.19
95% CI 1.09–1.30
Hysterectomyvs No hysterectomy
aOR 1.19 (95% CI 1.09–1.30)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Knee OA, hysterectomyvs no hysterectomy | 1.25 (1.13–1.38) | |
| OA by oestrogen therapy (ET) and hysterectomy, vs women who did not receive ETET alonevs No ET | 1.14 (1.07–1.23) | |
| OA by oestrogen therapy (ET) and hysterectomy, vs women who did not receive ETHysterectomy without ETvs No ET | 1.19 (1.08–1.31) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Hysterectomy and risk of osteoarthritis in women: a nationwide nested case–control study. Scand J Rheumatol. Published 16 January 2023. doi:10.
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