Potential surrogate outcomes in individuals at high risk for incident knee osteoarthritis
Authors' conclusion
Worsening of TF cartilage defects and TF osteophytes on MRI, and increased pain severity could be seen as surrogate outcomes for long-term OA incidence.
Study context
- Population
- Middle-aged women with overweight/obesity, free of knee symptoms, recruited through their general practitioners
- Outcome
- Association of short-term (2.5-year) changes in clinical and imaging biomarkers with incident clinical knee OA (combined ACR criteria)
- Follow-up
- 6.5 years
Methodological detailssurrogate outcome evaluation
- Surrogate outcome evaluation
Main finding
As reported in the abstract
Potential surrogate outcomes over 2.5 years associated with incident clinical knee OA
High specificity and NPV of these surrogate outcomes
89-91%
Low sensitivity and PPV of these surrogate outcomes
20-28%
Observational data: associations, not effects.
Original publication
Potential surrogate outcomes in individuals at high risk for incident knee osteoarthritis. Osteoarthritis Cartilage. Published 14 January 2023. doi:10.
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