Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: A systematic review
Authors' conclusion
These studies clearly show that there are a wide range of metabolic pathways perturbed in OA. For this period, there was no consensus on a single metabolite, or panel of metabolites, that would be clinically useful in early diagnosis of OA or distinguishing OA from a healthy control.
Study context
- Population
- Original reports of populations with diagnosed primary or secondary osteoarthritis (OA) (human) or surgically induced OA (animal) with a healthy control group43 articles
- Comparison
- OA vs healthy controls
- Outcome
- Metabolomic biomarkers and perturbed metabolic pathways in OA, evaluated by a priori p-values and/or AUC
Methodological detailsPubMed and Web of Science search to December 3rd, 2022, human and animal studies, 161 search results; 43 unique articles met inclusion criteria
- PubMed and Web of Science search to December 3rd, 2022
- Human and animal studies
- 161 search results; 43 unique articles met inclusion criteria
Pooled result
As reported in the abstract
Metabolic pathways perturbed in OA
- Studies by body fluid: urine
- 6
- Studies by body fluid: plasma
- 13
- Studies by body fluid: Synovial fluid (SF)
- 11
- Studies by body fluid: serum
- 11
- Studies by body fluid: SF and serum
- 1
- Studies by body fluid: plasma and SF
- 1
Original publication
Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: A systematic review. Semin Arthritis Rheum. Published 13 January 2023. doi:10.
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