Osteoarthritis

T-cell receptor repertoire and human leukocyte antigen (HLA) in osteoarthritis: A systematic literature review

Osteoarthritis CartilagePublished Systematic literature review

Authors' conclusion

This analysis highlights the paucity of usable data in the literature

Study context

Population
Articles on T-Cell Receptor (TCR), major histocompatibility complex (MHC) and T-cell antigens in human and animal research in osteoarthritis (OA)of 405 screened records
Participants
17 participants
Outcome
Topics of included articles (17 selected of 405 screened records; all human research)
Methodological detailsPRISMA 2020, PubMed and Embase, searched April 2024
  • PRISMA 2020
  • PubMed and Embase, searched April 2024

Main finding

As reported in the abstract

HLA as topic

65%

N=11

TCR repertoire as topic

41%

N=7

TCR articles: number of OA patients (mean ± SD)

4 ± 2

TCR articles using OA as a control disease

5 of 7

Original publication

T-cell receptor repertoire and HLA in osteoarthritis: A systematic literature review. Osteoarthritis Cartilage. Published 3 September 2025. doi:10.1016/j.joca.2025.08.018

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