The effects of losartan or angiotensin II receptor antagonists on cartilage: a systematic review
Authors' conclusion
Both in vitro and in vivo studies provide evidence to demonstrate beneficial effects of Ang II receptor antagonists on osteoarthritis and cartilage defect models across animal species.
Study context
- Population
- In vitro studies and in vivo animal studies of losartan or Ang II receptor antagonists on cartilage repair; PubMed, Embase, Cochrane Library searched up to November 12th 2021
- Participants
- 12 studies
- Comparison
- Losartan or Ang II receptor antagonists for cartilage repair
- Outcome
- Included studies by design
Methodological detailsqualitative evaluation (no meta-analysis), SYRCLE risk of bias tool, CAMARADES quality assessment
- Qualitative evaluation (no meta-analysis)
- SYRCLE risk of bias tool
- CAMARADES quality assessment
Pooled result
As reported in the abstract
In vitro human studies
2
In vitro animal studies
3
In vitro human and animal study
1
In vivo animal studies
6
Original publication
The effects of losartan or angiotensin II receptor antagonists on cartilage: a systematic review. Osteoarthritis Cartilage. Published 28 December 2022. doi:10.
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