Proportion of Acceptable Symptom State Nearly Tripled With Improvements in Patient‐Reported Outcomes for All Symptom State Subgroups: A Registry Study of More Than 15,000 Patients With Osteoarthritis in Digital Education and Exercise Therapy
Authors' conclusion
The percentage of participants achieving PASS almost tripled at 12 months.
Study context
- Population
- Individuals aged ≥40 years with knee or hip OA in a digital education and exercise therapy program
- Participants
- 15,253 individuals
- Exposure
- Persistently not achieving PASS (PNAP) vs early sustained PASS (ESP) vs gradually increasing satisfaction (GIS) vs Early patient acceptable symptom state (PASS), later unacceptable PASS
- Outcome
- Trajectories of patient acceptable symptom state (PASS)
- Follow-up
- 1 year after enrollment
Methodological detailsregistry study, group-based trajectory modeling, multinomial logistic regression, linear random intercept models
- Registry study
- Group-based trajectory modeling
- Multinomial logistic regression
- Linear random intercept models
Main finding
As reported in the abstract
Proportion reporting acceptable symptom state (PASS)
- PASS at enrollment
- 17.4% (95% CI 16.8%-18.1%)
- PASS at 3-month follow-up
- 42.4% (95% CI 41.6%-43.1%)
- PASS at 12-month follow-up
- 48.9% (95% CI 47.5%-50.2%)
- PNAP trajectory
- 45.1%
- ESP trajectory
- 34.8%
- GIS trajectory
- 10.8%
- Early PASS, later unacceptable PASS trajectory
- 9.3%
Observational data: associations, not effects.
Further findings
Baseline predictors of trajectories other than PNAP
- Female sex, older age, nonmetropolitan residence, lower education, knee OA, fear of movement, no walking difficulties, no wish for surgery and better patient-reported outcome measures (PROMs) generally associated with higher odds of trajectories other than PNAP
Change in PROMs across trajectories
- All trajectories improved in PROMs; generally larger improvements in ESP and GIS than the other two
Original publication
Proportion of Acceptable Symptom State Nearly Tripled With Improvements in Patient‐Reported Outcomes for All Symptom State Subgroups: A Registry Study of More Than 15,000 Patients With Osteoarthritis in Digital Education and Exercise Therapy. Arthritis Care Res (Hoboken). Published 25 September 2025. doi:10.
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