Personalised gait retraining for medial compartment knee osteoarthritis: a randomised controlled trial
Primary result · Medial knee pain (NRS), changeResult — go to the resultBetween-group difference −1.2 95% CI −1.9 to −0.5Authors' conclusion
Personalised foot angle modifications improve pain, reduce knee loading, and might slow osteoarthritis progression, making them a promising non-surgical treatment option for some individuals with medial compartment knee osteoarthritis.
Study context
- Population
- Adults (≥18 years) with symptomatic mild-to-moderate medial compartment knee OA, Stanford University, CA, USAmean age 64.4 years
- Participants
- 68 adults
- Comparison
- Personalised foot progression angle modification vs sham
- Interventionn = 34
- Shamn = 34reference
- Primary endpoint
- Co-primary: change in medial knee pain (NRS) and medial knee loading (knee adduction moment peak)
- Follow-up
- 1 year
Methodological detailssingle-centre, parallel-group, sham-controlled, participant- and analyst-masked
- Single-centre
- Parallel-group
- Sham-controlled
- Participant- and analyst-masked
Primary result
Medial knee pain (NRS), change
Between-group difference
−1.2
95% CI −1.9 to −0.5
P = 0.0013
Interventionvs Sham
between-group difference −1.2 (95% CI −1.9 to −0.5); P = 0.0013
As reported in the abstract
Secondary outcomes
| Outcome | Between-group difference (% bodyweight × height) (95% CI) | P value | |
|---|---|---|---|
| Co-primary: knee adduction moment peak, change · 1 year | −0.26 (−0.39 to −0.13) | P = 0.0001 | |
| −0.4−0.200.2Difference, % bodyweight × height (linear scale) |
| Outcome | Between-group difference (ms) (95% CI) | |
|---|---|---|
| Medial compartment cartilage microstructure (MRI T1ρ), change · 1 year | −3.74 (−6.42 to −1.05) | |
| −10−505Difference, ms (linear scale) |
Cartilage microstructure (MRI T2), change · 1 year
- No significant between-group differences in T2
Safety
Dropout due to increased knee pain
Severe adverse events
- No severe adverse events
Original publication
Personalised gait retraining for medial compartment knee osteoarthritis: a randomised controlled trial. Lancet Rheumatol. Published 12 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →