A virtual knee replacement (vKR) multi-component endpoint for knee osteoarthritis based on patient-reported patient-reported outcomes (PROs): Data from the Osteoarthritis Initiative
Authors' conclusion
The three vKR criteria represent potential clinical multi-component outcomes for clinical trials of knee OA.
Study context
- Population
- Osteoarthritis Initiative (OAI) participants with baseline radiographs, clinical assessments and health insurance, followed for 60 months8,205 knees
- Participants
- 4,143 participants
- Comparison
- vKR1 vs vKR2 vs vKR3
- Outcome
- Prediction of knee replacement in the next year (sensitivity, specificity, AUC)
- Follow-up
- Next year
Methodological detailslogistic regression, 60-month follow-up
- Logistic regression
- 60-month follow-up
Performance
As reported in the abstract
Prediction of knee replacement (KR) in the next year
| Test or model | AUC |
|---|---|
| vKR1 | 0.87 to 0.92 |
| vKR2 | exceeded 0.85 |
| vKR3 | >0.80 |
AUC
vKR10.87 to 0.92
vKR2exceeded 0.85
vKR3>0.80
- Odds of vKR increase per 10 points of these assessments
- 30 % to 65 %
Original publication
A virtual knee replacement (vKR) multi-component endpoint for knee osteoarthritis based on patient-reported PROs: Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. Published 6 August 2025. doi:10.
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