Plasma lipoprotein subclasses and risk of incident knee osteoarthritis: A population-based cohort study
Authors' conclusion
We provided novel evidence of diverse associations between lipoprotein subclasses and incident KOA and knee replacement, indicating the distinct effects of HDL subclasses.
Study context
- Population
- UK Biobank participants; 85 plasma lipoprotein subclasses defined by density, size and compositionmedian follow-up 12.8 years
- Participants
- 115,237 participants
- Exposure
- Plasma lipoprotein subclass concentrations and incident knee OA
- Outcome
- Incident knee OA
Methodological detailspopulation-based, UK Biobank, metabolome-wide analysis, Cox proportional hazards models, multiple-testing correction (0.05/9)
- Population-based
- UK Biobank
- Metabolome-wide analysis
- Cox proportional hazards models
- Multiple-testing correction (0.05/9)
Main finding
As reported in the abstract
Incident knee OA, per 1-SD increase in log-transformed lipoprotein subclass concentration
Lipoprotein subclasses significantly associated with incident knee OA
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Very-large and large high-density lipoproteins (HDL) (excluding triglyceride): lower risk, HRs ranging from
0.87 to 0.94
Small HDL, irrespective of composition: higher risk, HRs ranging from
1.04 to 1.09
Observational data: associations, not effects.
Further findings
Incident knee OA after adjustment for BMI as a continuous variable
- Differential effects among HDL subclasses remained evident, except for the association between large HDL and knee OA
Knee replacement (targeted analysis)
- Similar associations observed
Original publication
Plasma lipoprotein subclasses and risk of incident knee osteoarthritis: A population-based cohort study. Osteoarthritis Cartilage. Published 5 August 2025. doi:10.
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