Associations between total and regional fat-to-muscle mass ratio and osteoarthritis incidence: A prospective cohort study
Authors' conclusion
FMR was generally positively associated with osteoarthritis risk, with significant associations for arm and leg FMR remaining independent of body mass index across sex and age subgroups.
Study context
- Population
- Adults from the UK Biobank48,997 incident OA cases
- Participants
- 328,549 adults
- Exposure
- Per 1-SD increase in total and regional fat-to-muscle mass ratio
- Outcome
- Incident OA (ICD-10 codes)
Methodological detailsCox proportional-hazard regression, fully adjusted models, subgroup analyses by age, sex and joint site
- Cox proportional-hazard regression
- Fully adjusted models
- Subgroup analyses by age, sex and joint site
Main finding
As reported in the abstract
Incident OA per 1-SD increase in FMR, fully adjusted · median follow-up 14.4 years
Arm FMR, males: higher hazard
6%
Arm FMR, females: higher hazard
11%
Leg FMR, males: higher hazard
5%
Leg FMR, females: higher hazard
14%
Observational data: associations, not effects.
Original publication
Associations between total and regional fat-to-muscle mass ratio and osteoarthritis incidence: A prospective cohort study. Osteoarthritis Cartilage. Published 20 May 2025. doi:10.
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