The role of sex and systemic inflammation in the development of cardiovascular disease in osteoarthritis: A population-based cohort study using the CLSA
Main finding · CVD incidence/10,000 person-yearsResult — go to the resultHazard ratio 1.78 CI 1.22–2.58Authors' conclusion
CVD risk in females with OA is underestimated by the FRS, an algorithm often used in clinical settings. While increased systemic inflammation, a potential intervention target, contributes to the OA-CVD link in females, there remains still unexplained increased CVD risk in OA.
Study context
- Population
- Canadian Longitudinal Study on Aging respondents, cycles 1–3 (6 years of follow-up)age-sex-matched
- Participants
- 2,123 vs 2,123
- Exposure
- Osteoarthritis (OA) vs no OA
- OAn = 2,123
- No OAn = 2,123reference
- Outcome
- Time to CVD
- Follow-up
- 6 years
Methodological detailslongitudinal, age-sex-matched, Cox regression
- Longitudinal
- Age-sex-matched
- Cox regression
Main finding
CVD incidence/10,000 person-years
Hazard ratio
1.78
CI 1.22–2.58
OAvs No OA
HR 1.78 (CI 1.22–2.58)
As reported in the abstract
- Cardiovascular disease (CVD) incidence/10,000 person-years in females, OA vs no OA
- 123.0 and 65.0 (p = 0.008)
- CVD incidence/10,000 person-years in males, OA vs no OA
- 187.6 and 166.4 (p = 0.670)
Observational data: associations, not effects.
Further findings
Framingham Risk Score (FRS)-risk
- FRS-risk distribution similar for OA and non-OA; 'high-risk' FRS similarly associated with CVD for both sexes
Higher systemic inflammation and CVD risk (females)
- HR for CVD with higher systemic inflammation, females
- 1.77 (1.02, 3.05)
- In females only, OA associated with higher systemic inflammation
Original publication
The role of sex and systemic inflammation in the development of cardiovascular disease in osteoarthritis: A population-based cohort study using the CLSA. Semin Arthritis Rheum. Published 5 August 2025. doi:10.
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